Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC3976520 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Li Sai S Sieben Christian C Ludwig Kai K Höfer Chris T CT Chiantia Salvatore S Herrmann Andreas A Eghiaian Frederic F Schaap Iwan A T IA
Biophysical journal 20140401 7
Upon endocytosis in its cellular host, influenza A virus transits via early to late endosomes. To efficiently release its genome, the composite viral shell must undergo significant structural rearrangement, but the exact sequence of events leading to viral uncoating remains largely speculative. In addition, no change in viral structure has ever been identified at the level of early endosomes, raising a question about their role. We performed AFM indentation on single viruses in conjunction with ...[more]