Ontology highlight
ABSTRACT:
SUBMITTER: Laserson U
PROVIDER: S-EPMC3977259 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Laserson Uri U Vigneault Francois F Gadala-Maria Daniel D Yaari Gur G Uduman Mohamed M Vander Heiden Jason A JA Kelton William W Taek Jung Sang S Liu Yi Y Laserson Jonathan J Chari Raj R Lee Je-Hyuk JH Bachelet Ido I Hickey Brendan B Lieberman-Aiden Erez E Hanczaruk Bozena B Simen Birgitte B BB Egholm Michael M Koller Daphne D Georgiou George G Kleinstein Steven H SH Church George M GM
Proceedings of the National Academy of Sciences of the United States of America 20140317 13
The adaptive immune system confers protection by generating a diverse repertoire of antibody receptors that are rapidly expanded and contracted in response to specific targets. Next-generation DNA sequencing now provides the opportunity to survey this complex and vast repertoire. In the present work, we describe a set of tools for the analysis of antibody repertoires and their application to elucidating the dynamics of the response to viral vaccination in human volunteers. By analyzing data from ...[more]