Ontology highlight
ABSTRACT:
SUBMITTER: Shnyrova AV
PROVIDER: S-EPMC3980720 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130301 6126
Biological membrane fission requires protein-driven stress. The guanosine triphosphatase (GTPase) dynamin builds up membrane stress by polymerizing into a helical collar that constricts the neck of budding vesicles. How this curvature stress mediates nonleaky membrane remodeling is actively debated. Using lipid nanotubes as substrates to directly measure geometric intermediates of the fission pathway, we found that GTP hydrolysis limits dynamin polymerization into short, metastable collars that ...[more]