Ontology highlight
ABSTRACT:
SUBMITTER: Pannuzzo M
PROVIDER: S-EPMC6355196 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Pannuzzo Martina M McDargh Zachary A ZA Deserno Markus M
eLife 20181218
The large GTPase dynamin catalyzes membrane fission in eukaryotic cells, but despite three decades of experimental work, competing and partially conflicting models persist regarding some of its most basic actions. Here we investigate the mechanical and functional consequences of dynamin scaffold shape changes and disassembly with the help of a geometrically and elastically realistic simulation model of helical dynamin-membrane complexes. Beyond changes of radius and pitch, we emphasize the cruci ...[more]