RNA sequencing reveals upregulation of RUNX1-RUNX1T1 gene signatures in clear cell renal cell carcinoma.
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ABSTRACT:
SUBMITTER: Xiong Z
PROVIDER: S-EPMC3982423 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
RNA sequencing reveals upregulation of RUNX1-RUNX1T1 gene signatures in clear cell renal cell carcinoma.
Xiong Zuquan Z Yu Hongjie H Ding Yan Y Feng Chenchen C Wei Hanming H Tao Sha S Huang Dan D Zheng Siqun Lilly SL Sun Jielin J Xu Jianfeng J Fang Zujun Z
BioMed research international 20140325
In the past few years, therapies targeted at the von Hippel-Lindau (VHL) and hypoxia-inducible factor (HIF) pathways, such as sunitinib and sorafenib, have been developed to treat clear cell renal cell carcinoma (ccRCC). However, the majority of patients will eventually show resistance to antiangiogenesis therapies. The purpose of our study was to identify novel pathways that could be potentially used as targets for new therapies. Whole transcriptome sequencing (RNA-Seq) was conducted on eight m ...[more]
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