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Depression in Late-Life: a Focus on Prevention.


ABSTRACT: Depression is a leading cause of disease burden, disability and distress for millions of older adults. Thus, prevention of late-life depression is a priority research area. This article addresses the science of late-life depression prevention with the following: 1) an introduction to the Institute of Medicine framework of universal, selective and indicated prevention as it pertains to late-life depression, with particular attention to successes of indicated and selective prevention in primary care; 2) a discussion of how biomarkers can be integrated into prevention research, using interferon-alpha-induced depression as a model; 3) an outline for expansion of prevention to non-specialist care delivery systems in Low and Middle Income Countries - thus, extending the reach of current successful approaches; 4) a description of a novel approach to simultaneous testing of universal, selective and indicated prevention in late-life depression, with emphasis on study design features required to achieve practical, scalable tests of health impact.

SUBMITTER: Okereke OI 

PROVIDER: S-EPMC3982610 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Depression in Late-Life: a Focus on Prevention.

Okereke Olivia I OI   Lyness Jeffrey M JM   Lotrich Francis E FE   Reynolds Charles F CF  

Focus (American Psychiatric Publishing) 20130101 1


Depression is a leading cause of disease burden, disability and distress for millions of older adults. Thus, prevention of late-life depression is a priority research area. This article addresses the science of late-life depression prevention with the following: 1) an introduction to the Institute of Medicine framework of universal, selective and indicated prevention as it pertains to late-life depression, with particular attention to successes of indicated and selective prevention in primary ca  ...[more]

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