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Hepatitis C therapy with interferon-? and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.

ABSTRACT: Combined treatment with interferon alpha (IFN-?) and ribavirin (RBV) can effectively cure HCV infection in a significant proportion of patients, but effects of this regimen on cellular reservoirs for human immunodeficiency virus type 1 (HIV-1) are unknown. Here, we show that treatment with IFN-?/RBV led to a moderate but significant and sustained decline of HIV-1 DNA in CD4 T cells from HIV-1/hepatitis C virus-coinfected patients receiving highly active antiretroviral therapy (n = 12). However, in vitro experiments failed to demonstrate an effect of pharmacological doses of IFN-? on HIV-1 reactivation. Together, these data suggest that treatment with IFN-?/RBV can moderately reduce the reservoir of HIV-1-infected CD4 T cells that persists despite suppressive antiretroviral therapy.

SUBMITTER: Sun H 

PROVIDER: S-EPMC3982848 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients.

Sun Hong H   Buzon Maria J MJ   Shaw Amy A   Berg Randi Karteebahn RK   Yu Xu G XG   Ferrando-Martinez Sara S   Leal Manuel M   Ruiz-Mateos Ezequiel E   Lichterfeld Mathias M  

The Journal of infectious diseases 20131125 9

Combined treatment with interferon alpha (IFN-α) and ribavirin (RBV) can effectively cure HCV infection in a significant proportion of patients, but effects of this regimen on cellular reservoirs for human immunodeficiency virus type 1 (HIV-1) are unknown. Here, we show that treatment with IFN-α/RBV led to a moderate but significant and sustained decline of HIV-1 DNA in CD4 T cells from HIV-1/hepatitis C virus-coinfected patients receiving highly active antiretroviral therapy (n = 12). However,  ...[more]

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