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Implications of functional proteomics in breast cancer.

ABSTRACT: Breast cancer is one of the major public health problems of the Western world. Recent advances in genomics and gene expression-profiling approaches have enriched our understanding of this heterogeneous disease. However, progress in functional proteomics in breast cancer research has been relatively slow. Allied with genomics, the functional proteomics approach will be important in improving diagnosis through better classification of breast cancer and in predicting prognosis and response to different therapies, including chemotherapy, hormonal therapy, and targeted therapy. In this review, we will present functional proteomic approaches with a focus on the recent clinical implications of utilizing the reverse-phase protein array platform in breast cancer research.

SUBMITTER: Chae YK

PROVIDER: S-EPMC3983827 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Implications of functional proteomics in breast cancer.

Chae Young Kwang YK Gonzalez-Angulo Ana Maria AM

The oncologist 20140324 4

Breast cancer is one of the major public health problems of the Western world. Recent advances in genomics and gene expression-profiling approaches have enriched our understanding of this heterogeneous disease. However, progress in functional proteomics in breast cancer research has been relatively slow. Allied with genomics, the functional proteomics approach will be important in improving diagnosis through better classification of breast cancer and in predicting prognosis and response to diffe ...[more]

PMID: 24664486

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