Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle.
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ABSTRACT:
SUBMITTER: Ducceschi M
PROVIDER: S-EPMC3983900 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscle.
Ducceschi Melissa M Clifton Lisa G LG Stimpson Stephen A SA Billin Andrew N AN
Journal of molecular histology 20140202 3
We have identified integrin beta 6 (Itgb6) as a transcript highly enriched in skeletal muscle. This finding is unexpected because Itgb6 is typically associated with epithelial expression domains in normal tissue. Further we find that ITGB6 protein expression in muscle is post-transcriptionally regulated. Uninjured muscle expresses Itgb6 RNA but no ITGB6 protein is detectable. Muscle injury induces ITGB6 protein accumulation rapidly post-injury in myofibers adjacent to the site of injury. As rege ...[more]
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