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CD169? macrophages provide a niche promoting erythropoiesis under homeostasis and stress.

ABSTRACT: A role for macrophages in erythropoiesis was suggested several decades ago when erythroblastic islands in the bone marrow, composed of a central macrophage surrounded by developing erythroblasts, were described. However, the in vivo role of macrophages in erythropoiesis under homeostatic conditions or in disease remains unclear. We found that specific depletion of CD169(+) macrophages markedly reduced the number of erythroblasts in the bone marrow but did not result in overt anemia under homeostatic conditions, probably because of concomitant alterations in red blood cell clearance. However, CD169(+) macrophage depletion significantly impaired erythropoietic recovery from hemolytic anemia, acute blood loss and myeloablation. Furthermore, macrophage depletion normalized the erythroid compartment in a JAK2(V617F)-driven mouse model of polycythemia vera, suggesting that erythropoiesis in polycythemia vera remains under the control of macrophages in the bone marrow and splenic microenvironments. These results indicate that CD169(+) macrophages promote late erythroid maturation and that modulation of the macrophage compartment may be a new strategy to treat erythropoietic disorders.

SUBMITTER: Chow A

PROVIDER: S-EPMC3983996 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.

Chow Andrew A Huggins Matthew M Ahmed Jalal J Hashimoto Daigo D Lucas Daniel D Kunisaki Yuya Y Pinho Sandra S Leboeuf Marylene M Noizat Clara C van Rooijen Nico N Tanaka Masato M Zhao Zhizhuang Joe ZJ Bergman Aviv A Merad Miriam M Frenette Paul S PS

Nature medicine 20130317 4

A role for macrophages in erythropoiesis was suggested several decades ago when erythroblastic islands in the bone marrow, composed of a central macrophage surrounded by developing erythroblasts, were described. However, the in vivo role of macrophages in erythropoiesis under homeostatic conditions or in disease remains unclear. We found that specific depletion of CD169(+) macrophages markedly reduced the number of erythroblasts in the bone marrow but did not result in overt anemia under homeost ...[more]

PMID: 23502962

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Dataset Information

CD169? macrophages provide a niche promoting erythropoiesis under homeostasis and stress.

Publications

CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.

Similar Datasets

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