Ontology highlight
ABSTRACT:
SUBMITTER: Hao S
PROVIDER: S-EPMC6650738 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Hao Siyang S Xiang Jie J Wu Dai-Chen DC Fraser James W JW Ruan Baiye B Cai Jingwei J Patterson Andrew D AD Lai Zhi-Chun ZC Paulson Robert F RF
Blood advances 20190701 14
Anemic stress induces the proliferation of stress erythroid progenitors in the murine spleen that subsequently differentiate to generate erythrocytes to maintain homeostasis. This process relies on the interaction between stress erythroid progenitors and the signals generated in the splenic erythroid niche. In this study, we demonstrate that although growth-differentiation factor 15 (Gdf15) is not required for steady-state erythropoiesis, it plays an essential role in stress erythropoiesis. Gdf1 ...[more]