Ontology highlight
ABSTRACT:
SUBMITTER: Tsaalbi-Shtylik A
PROVIDER: S-EPMC3985633 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Tsaalbi-Shtylik Anastasia A Moser Jill J Mullenders Leon H F LH Jansen Jacob G JG de Wind Niels N
Nucleic acids research 20140123 7
Rev3, the catalytic subunit of DNA polymerase ζ, is essential for translesion synthesis of cytotoxic DNA photolesions, whereas the Rev1 protein plays a noncatalytic role in translesion synthesis. Here, we reveal that mammalian Rev3(-/-) and Rev1(-/-) cell lines additionally display a nucleotide excision repair (NER) defect, specifically during S phase. This defect is correlated with the normal recruitment but protracted persistence at DNA damage sites of factors involved in an early stage of NER ...[more]