Ontology highlight
ABSTRACT:
SUBMITTER: Bass TE
PROVIDER: S-EPMC5245861 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Bass Thomas E TE Luzwick Jessica W JW Kavanaugh Gina G Carroll Clinton C Dungrawala Huzefa H Glick Gloria G GG Feldkamp Michael D MD Putney Reid R Chazin Walter J WJ Cortez David D
Nature cell biology 20161010 11
The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication stress response protein in two proteomic screens. ETAA1-deficient cells accumulate double-strand breaks, sister chromatid exchanges, and other hallmarks of genome instability. They are also hypersensitive to replication stress and have increased fr ...[more]