Ontology highlight
ABSTRACT:
SUBMITTER: Das BB
PROVIDER: S-EPMC3985661 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Das Benu Brata BB Huang Shar-yin N SY Murai Junko J Rehman Ishita I Amé Jean-Christophe JC Sengupta Souvik S Das Subhendu K SK Majumdar Papiya P Zhang Hongliang H Biard Denis D Majumder Hemanta K HK Schreiber Valérie V Pommier Yves Y
Nucleic acids research 20140203 7
Poly(ADP-ribose) polymerases (PARP) attach poly(ADP-ribose) (PAR) chains to various proteins including themselves and chromatin. Topoisomerase I (Top1) regulates DNA supercoiling and is the target of camptothecin and indenoisoquinoline anticancer drugs, as it forms Top1 cleavage complexes (Top1cc) that are trapped by the drugs. Endogenous and carcinogenic DNA lesions can also trap Top1cc. Tyrosyl-DNA phosphodiesterase 1 (TDP1), a key repair enzyme for trapped Top1cc, hydrolyzes the phosphodieste ...[more]