Ontology highlight
ABSTRACT:
SUBMITTER: Castelnuovo M
PROVIDER: S-EPMC3985671 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Castelnuovo Manuele M Zaugg Judith B JB Guffanti Elisa E Maffioletti Andrea A Camblong Jurgi J Xu Zhenyu Z Clauder-Münster Sandra S Steinmetz Lars M LM Luscombe Nicholas M NM Stutz Françoise F
Nucleic acids research 20140204 7
Most genomes, including yeast Saccharomyces cerevisiae, are pervasively transcribed producing numerous non-coding RNAs, many of which are unstable and eliminated by nuclear or cytoplasmic surveillance pathways. We previously showed that accumulation of PHO84 antisense RNA (asRNA), in cells lacking the nuclear exosome component Rrp6, is paralleled by repression of sense transcription in a process dependent on the Hda1 histone deacetylase (HDAC) and the H3K4 histone methyl transferase Set1. Here w ...[more]