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Protein and enzyme gated supramolecular disassembly.

ABSTRACT: An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such supramolecular disassembly principles could have broad implications in a variety of biological applications.

SUBMITTER: Guo J

PROVIDER: S-EPMC3985736 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Protein and enzyme gated supramolecular disassembly.

Guo Jing J Zhuang Jiaming J Wang Feng F Raghupathi Krishna R KR Thayumanavan S S

Journal of the American Chemical Society 20140129 6

An amphiphilic nanoassembly was designed to respond to the concurrent presence of a protein and an enzyme. We present herein a system, where in the presence of these two stimuli supramolecular disassembly and molecular release occur. This molecular release arises in the form a fluorescence response that has been shown to be specific. We also show that this system can be modified to respond only if light stimulus is also present in addition to the protein and the enzyme. Demonstration of such sup ...[more]

PMID: 24447098

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