Ontology highlight
ABSTRACT:
SUBMITTER: German AE
PROVIDER: S-EPMC3986673 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Journal of cell science 20140212 Pt 8
Although a number of growth factors and receptors are known to control tumor angiogenesis, relatively little is known about the mechanism by which these factors influence the directional endothelial cell migration required for cancer microvessel formation. Recently, it has been shown that the focal adhesion protein paxillin is required for directional migration of fibroblasts in vitro. Here, we show that paxillin knockdown enhances endothelial cell migration in vitro and stimulates angiogenesis ...[more]