Ontology highlight
ABSTRACT:
SUBMITTER: Tsang WY
PROVIDER: S-EPMC3987787 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Tsang William Y WY Bossard Carine C Khanna Hemant H Peränen Johan J Swaroop Anand A Malhotra Vivek V Dynlacht Brian David BD
Developmental cell 20080801 2
Primary cilia are nonmotile organelles implicated in signaling and sensory functions. Understanding how primary cilia assemble could shed light on the many human diseases caused by mutations in ciliary proteins. The centrosomal protein CP110 is known to suppress ciliogenesis through an unknown mechanism. Here, we report that CP110 interacts with CEP290--a protein whose deficiency is implicated in human ciliary disease--in a discrete complex separable from other CP110 complexes involved in regula ...[more]