Ontology highlight
ABSTRACT:
SUBMITTER: Walentek P
PROVIDER: S-EPMC5045295 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Walentek Peter P Quigley Ian K IK Sun Dingyuan I DI Sajjan Umeet K UK Kintner Christopher C Harland Richard M RM
eLife 20160913
Upon cell cycle exit, centriole-to-basal body transition facilitates cilia formation. The centriolar protein Cp110 is a regulator of this process and cilia inhibitor, but its positive roles in ciliogenesis remain poorly understood. Using <i>Xenopus</i> we show that Cp110 inhibits cilia formation at high levels, while optimal levels promote ciliogenesis. Cp110 localizes to cilia-forming basal bodies and rootlets, and is required for ciliary adhesion complexes that facilitate Actin interactions. T ...[more]