Dataset Information

Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis.

ABSTRACT:

Background

Previous studies have yielded conflicting results regarding the relationship between p53 status and response to chemotherapy in patients with gastric cancer. We therefore performed a meta-analysis to expound the relationship between p53 status and response to chemotherapy.

Methods/findings

Thirteen previously published eligible studies, including 564 cases, were identified and included in this meta-analysis. p53 positive status (high expression of p53 protein and/or a mutant p53 gene) was associated with improved response in gastric cancer patients who received chemotherapy (good response: risk ratio [RR] = 0.704; 95% confidence intervals [CI] = 0.550-0.903; P = 0.006). In further stratified analyses, association with a good response remained in the East Asian population (RR = 0.657; 95% CI = 0.488-0.884; P = 0.005), while in the European subgroup, patients with p53 positive status tended to have a good response to chemotherapy, although this did not reach statistical significance (RR = 0.828, 95% CI = 0.525-1.305; P = 0.417). As five studies used neoadjuvant chemotherapy (NCT) and one used neoadjuvant chemoradiotherapy (NCRT), we also analyzed these data, and found that p53 positive status was associated with a good response in gastric cancer patients who received chemotherapy-based neoadjuvant treatment (RR = 0.675, 95% CI = 0.463-0.985; P = 0.042).

Conclusion

This meta-analysis indicated that p53 status may be a useful predictive biomarker for response to chemotherapy in gastric cancer. Further prospective studies with larger sample sizes and better study designs are required to confirm our findings.

SUBMITTER: Xu HY

PROVIDER: S-EPMC3989310 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis.

Xu Hai-Yuan HY Xu Wen-Lin WL Wang Li-Qiang LQ Chen Min-Bin MB Shen Hui-Ling HL

PloS one 20140416 4

<h4>Background</h4>Previous studies have yielded conflicting results regarding the relationship between p53 status and response to chemotherapy in patients with gastric cancer. We therefore performed a meta-analysis to expound the relationship between p53 status and response to chemotherapy.<h4>Methods/findings</h4>Thirteen previously published eligible studies, including 564 cases, were identified and included in this meta-analysis. p53 positive status (high expression of p53 protein and/or a m ...[more]

PMID: 24740294

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Dataset Information

Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis.

Background

Methods/findings

Conclusion

Publications

Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis.

Similar Datasets

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