Ontology highlight
ABSTRACT:
SUBMITTER: Zhao G
PROVIDER: S-EPMC3989392 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Zhao Guohui G Wu Baolin B Li Lei L Wang Peng George PG
Applied microbiology and biotechnology 20140221 9
Bacterial lipopolysaccharide (LPS) is an essential cell envelope component for gram-negative bacteria. As the most variable region of LPS, O antigens serve as important virulence determinants for many bacteria and represent a promising carbohydrate source for glycoconjugate vaccines. In the Wzy-dependent O-antigen biosynthetic pathway, the integral membrane protein Wzy was shown to be the sole enzyme responsible for polymerization of O-repeat unit. Its catalytic mechanism, however, remains elusi ...[more]