Ontology highlight
ABSTRACT:
SUBMITTER: Zinin N
PROVIDER: S-EPMC3989669 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Zinin Nikolay N Adameyko Igor I Wilhelm Margareta M Fritz Nicolas N Uhlén Per P Ernfors Patrik P Henriksson Marie Arsenian MA
EMBO reports 20140305 4
The role of MYC proteins in somatic stem and progenitor cells during development is poorly understood. We have taken advantage of a chick in vivo model to examine their role in progenitor cells of the developing neural tube. Our results show that depletion of endogenous MYC in radial glial precursors (RGPs) is incompatible with differentiation and conversely, that overexpression of MYC induces neurogenesis independently of premature or upregulated expression of proneural gene programs. Unexpecte ...[more]