Ontology highlight
ABSTRACT:
SUBMITTER: Ferreiros-Vidal I
PROVIDER: S-EPMC6481923 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ferreirós-Vidal Isabel I Carroll Thomas T Zhang Tianyi T Lagani Vincenzo V Ramirez Ricardo N RN Ing-Simmons Elizabeth E Gómez-Valadés Alicia G AG Cooper Lee L Liang Ziwei Z Papoutsoglou Georgios G Dharmalingam Gopuraja G Guo Ya Y Tarazona Sonia S Fernandes Sunjay J SJ Noori Peri P Silberberg Gilad G Fisher Amanda G AG Tsamardinos Ioannis I Mortazavi Ali A Lenhard Boris B Conesa Ana A Tegner Jesper J Merkenschlager Matthias M Gomez-Cabrero David D
PLoS biology 20190412 4
The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle states are coordinated with the regulation of cell type-specific genes is an important question, because dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. He ...[more]