Ontology highlight
ABSTRACT:
SUBMITTER: Hein JB
PROVIDER: S-EPMC3989692 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
EMBO reports 20140125 3
The spindle assembly checkpoint (SAC) delays progression into anaphase until all chromosomes have aligned on the metaphase plate by inhibiting Cdc20, the mitotic co-activator of the APC/C. Mad2 and BubR1 bind and inhibit Cdc20, thereby forming the mitotic checkpoint complex (MCC), which can bind stably to the APC/C. Whether MCC formation per se is sufficient for a functional SAC or MCC association with the APC/C is required remains unclear. Here, we analyze the role of two conserved motifs in Cd ...[more]