Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC3990191 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Liu Xiaoqian X Jin Zhicheng Z O'Brien Richard R Bathon Joan J Dietz Harry C HC Grote Eric E Van Eyk Jennifer E JE
Methods (San Diego, Calif.) 20130322 3
Selected reaction monitoring (SRM) is a mass spectrometry method that can target signature peptides to provide for the detection and quantitation of specific proteins in complex biological samples. When quantifying a protein, multiple peptides are generated using a specific protease such as trypsin, thereby allowing a choice of signature peptides with robust signals. In contrast, signature peptide selection can be constrained when the goal is to monitor a specific post-translational modification ...[more]