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Intratumoral CD8? cytotoxic lymphocyte is a favorable prognostic marker in node-negative breast cancer.


ABSTRACT:

Background

The prognostic effect of tumor infiltrating CD8+ cytotoxic lymphocytes (CTLs) in breast cancer is controversial. We analyzed the association between CD8+ CTLs and survival of untreated node-negative breast cancer patients.

Material and methods

CD8+ CTLs infiltrate was evaluated by immunostaining in a cohort of 332 node-negative breast cancer patients with a median follow-up of 152 months. The prognostic significance of CD8+ CTLs for disease-free survival (DFS) and breast cancer-specific overall survival (OS) was evaluated with Kaplan-Meier survival analysis as well as univariate analysis and multivariate Cox analysis adjusted for age at diagnosis, pT stage, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 expression and human epidermal growth factor receptor 2 (HER-2) status.

Results

285 (85.8%) patients showed strong CD8+ CTLs infiltrate positive status. Univariate analysis showed that CD8+ CTLs had statistically significant association with DFS (P?=?0.004, hazard ratio [HR]?=?0.454, 95% confidence interval [CI]?=?0.265-0.777) and OS (P?=?0.014, HR?=?0.430, 95% CI?=?0.220-0.840) in the entire cohort. The significance of CD8+ CTLs was especially strong in ER negative, HER-2 negative and ER, PR, HER-2 triple-negative breast cancers. In Kaplan-Meier analysis, CD8+ CTLs had significant effect on prognosis of patients (Log-rank test: P?=?0.003 for DFS and P?=?0.011 for OS), independent of established clinical factors for DFS (P?=?0.002, HR?=?0.418, 95% CI?=?0.242-0.724) as well as for OS (P?=?0.009, HR?=?0.401, 95% CI?=?0.202-0.797).

SUBMITTER: Chen Z 

PROVIDER: S-EPMC3990637 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Intratumoral CD8⁺ cytotoxic lymphocyte is a favorable prognostic marker in node-negative breast cancer.

Chen Zonglin Z   Chen Xianyu X   Zhou Enxiang E   Chen Ganlong G   Qian Ke K   Wu Xia X   Miao Xiongying X   Tang Zhonghua Z  

PloS one 20140417 4


<h4>Background</h4>The prognostic effect of tumor infiltrating CD8+ cytotoxic lymphocytes (CTLs) in breast cancer is controversial. We analyzed the association between CD8+ CTLs and survival of untreated node-negative breast cancer patients.<h4>Material and methods</h4>CD8+ CTLs infiltrate was evaluated by immunostaining in a cohort of 332 node-negative breast cancer patients with a median follow-up of 152 months. The prognostic significance of CD8+ CTLs for disease-free survival (DFS) and breas  ...[more]

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