Ontology highlight
ABSTRACT:
SUBMITTER: Pinto AK
PROVIDER: S-EPMC3990718 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Pinto Amelia K AK Ramos Hilario J HJ Wu Xiaobo X Aggarwal Shilpa S Shrestha Bimmi B Gorman Matthew M Kim Kristin Y KY Suthar Mehul S MS Atkinson John P JP Gale Michael M Diamond Michael S MS
PLoS pathogens 20140417 4
The type I interferon (IFN) signaling response limits infection of many RNA and DNA viruses. To define key cell types that require type I IFN signaling to orchestrate immunity against West Nile virus (WNV), we infected mice with conditional deletions of the type I IFN receptor (IFNAR) gene. Deletion of the Ifnar gene in subsets of myeloid cells resulted in uncontrolled WNV replication, vasoactive cytokine production, sepsis, organ damage, and death that were remarkably similar to infection of If ...[more]