Ontology highlight
ABSTRACT:
SUBMITTER: Zadra G
PROVIDER: S-EPMC3992078 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Zadra Giorgia G Photopoulos Cornelia C Tyekucheva Svitlana S Heidari Pedram P Weng Qing Ping QP Fedele Giuseppe G Liu Hong H Scaglia Natalia N Priolo Carmen C Sicinska Ewa E Mahmood Umar U Signoretti Sabina S Birnberg Neal N Loda Massimo M
EMBO molecular medicine 20140204 4
5'AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of mTORC1 pathway. However, whether AMPK activation itself is sufficient to block cancer cell growth remains to be determined. A small molecule screening was performed and identified MT 63-78, a specific and potent direct AMPK activator. Here, we show that direct activation of AMP ...[more]