Ontology highlight
ABSTRACT:
SUBMITTER: Edris B
PROVIDER: S-EPMC3992120 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Edris Badreddin B Espinosa Iñigo I Mühlenberg Thomas T Mikels Amanda A Lee Cheng-Han CH Steigen Sonja E SE Zhu Shirley S Montgomery Kelli D KD Lazar Alexander J F AJ Lev Dina D Fletcher Jonathan A JA Beck Andrew H AH West Robert B RB Nusse Roel R van de Rijn Matt M
The Journal of pathology 20120217 2
Soft-tissue sarcomas are a group of malignant tumours whose clinical management is complicated by morphological heterogeneity, inadequate molecular markers and limited therapeutic options. Receptor tyrosine kinases (RTKs) have been shown to play important roles in cancer, both as therapeutic targets and as prognostic biomarkers. An initial screen of gene expression data for 48 RTKs in 148 sarcomas showed that ROR2 was expressed in a subset of leiomyosarcoma (LMS), gastrointestinal stromal tumour ...[more]