Dataset Information

Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.

ABSTRACT:

Background

Accumulating evidence indicates that tumour-infiltrating lymphocytes (TILs) are the primary determinant of survival outcomes in various tumours. Thus, we sought to investigate the TIL distribution and density in gastrointestinal stromal tumours (GISTs) and to develop an immune infiltration (II)-based signature to predict prognosis.

Methods

The expression of 8 immune features in the tumour centre (TC) and tumour margin (TM) and PD-L1 in 435 GIST patients was investigated by immunohistochemistry. Then, a 4-feature-based II-GIST signature integrating the CD3⁺ TC, CD3⁺ TM, CD8⁺ TM and CD45RO⁺ TM parameters was developed using a LASSO Cox regression model in the training cohort and was validated in two separate validation cohorts.

Findings

High CD3⁺ TC, CD3⁺ TM, CD8⁺ TC, CD8⁺ TM, CD45RO⁺ TM, NKp46⁺ TM and CD20⁺ TM correlated with improved survival. Patients with high II-GIST scores have better RFS and OS outcomes than those with low II-GIST scores. Multivariable analyses demonstrated that the II-GIST signature is an independent prognostic factor. The receiver operating characteristic (ROC) curve demonstrated that the prognostic accuracy of the II-GIST signature is superior to that of the NIH risk criteria. Further analysis showed that moderate- and high-risk GIST patients with high II-GIST scores could gain survival benefits from adjuvant imatinib therapy.

Interpretation

The novel II-GIST signature accurately predicted the survival outcomes of GIST patients. In addition, the II-GIST signature was a useful predictor of survival benefit from imatinib therapy amongst moderate- and high-risk patients with GIST.

Funding

This project was supported by National Natural Science Foundation of China (81702325), Natural Science Foundation of Guangdong Province (2017A030310565), and 3&3 Project of the First Affiliated Hospital of Sun Yat-sen University.

SUBMITTER: Wei ZW

PROVIDER: S-EPMC7322257 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Publications

Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.

Wei Zhe-Wei ZW Wu Jing J Huang Wei-Bin WB Li Jin J Lu Xiao-Fang XF Yuan Yu-Jie YJ Xiong Wen-Jun WJ Zhang Xin-Hua XH Wang Wei W He Yu-Long YL Zhang Chang-Hua CH

EBioMedicine 20200620

<h4>Background</h4>Accumulating evidence indicates that tumour-infiltrating lymphocytes (TILs) are the primary determinant of survival outcomes in various tumours. Thus, we sought to investigate the TIL distribution and density in gastrointestinal stromal tumours (GISTs) and to develop an immune infiltration (II)-based signature to predict prognosis.<h4>Methods</h4>The expression of 8 immune features in the tumour centre (TC) and tumour margin (TM) and PD-L1 in 435 GIST patients was investigated ...[more]

PMID: 32574962

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Dataset Information

Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.

Background

Methods

Findings

Interpretation

Funding

Publications

Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.

Similar Datasets

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