Ontology highlight
ABSTRACT:
SUBMITTER: Blackburn JS
PROVIDER: S-EPMC3992437 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Blackburn Jessica S JS Liu Sali S Wilder Jayme L JL Dobrinski Kimberly P KP Lobbardi Riadh R Moore Finola E FE Martinez Sarah A SA Chen Eleanor Y EY Lee Charles C Langenau David M DM
Cancer cell 20140306 3
Clonal evolution and intratumoral heterogeneity drive cancer progression through unknown molecular mechanisms. To address this issue, functional differences between single T cell acute lymphoblastic leukemia (T-ALL) clones were assessed using a zebrafish transgenic model. Functional variation was observed within individual clones, with a minority of clones enhancing growth rate and leukemia-propagating potential with time. Akt pathway activation was acquired in a subset of these evolved clones, ...[more]