Ontology highlight
ABSTRACT:
SUBMITTER: Shi C
PROVIDER: S-EPMC3992484 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Shi Chanjuan C Washington M Kay MK Chaturvedi Rupesh R Drosos Yiannis Y Revetta Frank L FL Weaver Connie J CJ Buzhardt Emily E Yull Fiona E FE Blackwell Timothy S TS Sosa-Pineda Beatriz B Whitehead Robert H RH Beauchamp R Daniel RD Wilson Keith T KT Means Anna L AL
Laboratory investigation; a journal of technical methods and pathology 20140217 4
Pancreatic cancer occurs in the setting of a profound fibrotic microenvironment that often dwarfs the actual tumor. Although pancreatic fibrosis has been well studied in chronic pancreatitis, its development in pancreatic cancer is much less well understood. This article describes the dynamic remodeling that occurs from pancreatic precursors (pancreatic intraepithelial neoplasias (PanINs)) to pancreatic ductal adenocarcinoma, highlighting similarities and differences between benign and malignant ...[more]