Ontology highlight
ABSTRACT:
SUBMITTER: Birtolo C
PROVIDER: S-EPMC5225304 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Birtolo Chiara C Pham Hung H Morvaridi Susan S Chheda Chintan C Go Vay Liang W VL Ptasznik Andrzej A Edderkaoui Mouad M Weisman Michael H MH Noss Erika E Brenner Michael B MB Larson Brent B Guindi Maha M Wang Qiang Q Pandol Stephen J SJ
The American journal of pathology 20161114 1
Chronic pancreatitis is a prominent risk factor for the development of pancreatic ductal adenocarcinoma. In both conditions, the activation of myofibroblast-like pancreatic stellate cells (PSCs) plays a predominant role in the formation of desmoplastic reaction through the synthesis of connective tissue and extracellular matrix, inducing local pancreatic fibrosis and an inflammatory response. Yet the signaling events involved in chronic pancreatitis and pancreatic cancer progression and metastas ...[more]