Mechanism of Escherichia coli resistance to Pyrrhocoricin.
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ABSTRACT:
SUBMITTER: Narayanan S
PROVIDER: S-EPMC3993218 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Mechanism of Escherichia coli resistance to Pyrrhocoricin.
Narayanan Shalini S Modak Joyanta K JK Ryan Catherine S CS Garcia-Bustos Jose J Davies John K JK Roujeinikova Anna A
Antimicrobial agents and chemotherapy 20140303 5
Due to their lack of toxicity to mammalian cells and good serum stability, proline-rich antimicrobial peptides (PR-AMPs) have been proposed as promising candidates for the treatment of infections caused by antimicrobial-resistant bacterial pathogens. It has been hypothesized that these peptides act on multiple targets within bacterial cells, and therefore the likelihood of the emergence of resistance was considered to be low. Here, we show that spontaneous Escherichia coli mutants resistant to p ...[more]
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