Ontology highlight
ABSTRACT:
SUBMITTER: Cockrell AS
PROVIDER: S-EPMC3993820 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Cockrell Adam S AS Peck Kayla M KM Yount Boyd L BL Agnihothram Sudhakar S SS Scobey Trevor T Curnes Nicole R NR Baric Ralph S RS Heise Mark T MT
Journal of virology 20140226 9
Human dipeptidyl peptidase 4 (hDPP4) was recently identified as the receptor for Middle East respiratory syndrome coronavirus (MERS-CoV) infection, suggesting that other mammalian DPP4 orthologs may also support infection. We demonstrate that mouse DPP4 cannot support MERS-CoV infection. However, employing mouse DPP4 as a scaffold, we identified two critical amino acids (A288L and T330R) that regulate species specificity in the mouse. This knowledge can support the rational design of a mouse-ada ...[more]