Ontology highlight
ABSTRACT:
SUBMITTER: Tardiff DF
PROVIDER: S-EPMC3993916 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Tardiff Daniel F DF Jui Nathan T NT Khurana Vikram V Tambe Mitali A MA Thompson Michelle L ML Chung Chee Yeun CY Kamadurai Hari B HB Kamadurai Hari B HB Kim Hyoung Tae HT Lancaster Alex K AK Caldwell Kim A KA Caldwell Guy A GA Rochet Jean-Christophe JC Buchwald Stephen L SL Lindquist Susan S
Science (New York, N.Y.) 20131024 6161
α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson's disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodegenerative disease. Using unbiased phenotypic screens as an alternative to target-based approaches, we discovered an N-aryl benzimidazole (NAB) that strongly and selectively protected diverse cell types from ...[more]