A novel autophagy modulator 6-Bio ameliorates SNCA/?-synuclein toxicity.
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ABSTRACT:
SUBMITTER: Suresh SN
PROVIDER: S-EPMC5529071 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity.
Suresh S N SN Chavalmane Aravinda K AK Dj Vidyadhara V Yarreiphang Haorei H Rai Shashank S Paul Abhik A Clement James P JP Alladi Phalguni Anand PA Manjithaya Ravi R
Autophagy 20170328 7
Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein implicated in synucleopathies) aggregates in yeast and mammalian cell lines. 6-Bio induces autophagy and dramatically enhances autolysosome formation resulting in SNCA degradation. Importantly, neuroprotective function of 6-Bio as envisaged by immunohistology a ...[more]
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