Ontology highlight
ABSTRACT:
SUBMITTER: Bottorff SC
PROVIDER: S-EPMC3993946 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Inorganic chemistry 20140131 4
Isoxazole ring formation was examined as a potential Cu-free alternative click reaction to Cu(I)-catalyzed alkyne/azide cycloaddition. The isoxazole reaction was explored at macroscopic and radiotracer concentrations with the fac-[M(I)(CO)3](+) (M = Re, (99m)Tc) core for use as a noncoordinating linker strategy between covalently linked molecules. Two click assembly methods (click, then chelate and chelate, then click) were examined to determine the feasibility of isoxazole ring formation with e ...[more]