Gankyrin is frequently overexpressed in cervical high grade disease and is associated with cervical carcinogenesis and metastasis.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3994022 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Gankyrin is frequently overexpressed in cervical high grade disease and is associated with cervical carcinogenesis and metastasis.
Liu Yuan Y Zhang Jiawen J Qian Wenyan W Dong Yu Y Yang Yongbin Y Liu Zhiqiang Z Feng Youji Y Ma Ding D Zhang Zhenbo Z Wu Sufang S
PloS one 20140421 4
Our previous studies have showed that Gankyrin expression is correlated with a malignant phenotype in endometrial carcinoma. Here, we investigated the possible role of Gankyrin in cervical disease. The increasing protein level of Gankyrin was observed in high-grade cervical intraepithelial neoplasia and carcinoma compared with benign cervical tissues and low-grade cervical intraepithelial neoplasia. In para-carcinoma tissues, it was found interestingly that there was no lymph node metastasis whe ...[more]
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