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Human papillomavirus 16 non-European variants are preferentially associated with high-grade cervical lesions.


ABSTRACT: HPV16 accounts for 50-70% of cervical cancer cases worldwide. Characterization of HPV16 variants previously indicated that they differ in risks for viral persistence, progression to cervical precancer and malignant cancer. The aim of this study was to examine the association of severity of disease with HPV16 variants identified in specimens (n?=?281) obtained from a Cervical Pathology and Colposcopy outpatient clinic in the University Hospital of Espírito Santo State, Southeastern Brazil, from April 2010 to November 2011. All cytologic and histologic diagnoses were determined prior to definitive treatment. The DNA was isolated using QIAamp DNA Mini Kit and HPV was detected by amplification with PGMY09/11 primers and positive samples were genotyped by RFLP analyses and reverse line blot. The genomes of the HPV16 positive samples were sequenced, from which variant lineages were determined. Chi2 statistics was performed to test the association of HPV16 variants between case and control groups. The prevalence of HR-HPV types in

SUBMITTER: Freitas LB 

PROVIDER: S-EPMC4077691 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Human papillomavirus 16 non-European variants are preferentially associated with high-grade cervical lesions.

Freitas Luciana Bueno LB   Chen Zigui Z   Muqui Elaine Freire EF   Boldrini Neide Aparecida Tosato NA   Miranda Angélica Espinosa AE   Spano Liliana Cruz LC   Burk Robert D RD  

PloS one 20140701 7


HPV16 accounts for 50-70% of cervical cancer cases worldwide. Characterization of HPV16 variants previously indicated that they differ in risks for viral persistence, progression to cervical precancer and malignant cancer. The aim of this study was to examine the association of severity of disease with HPV16 variants identified in specimens (n = 281) obtained from a Cervical Pathology and Colposcopy outpatient clinic in the University Hospital of Espírito Santo State, Southeastern Brazil, from A  ...[more]

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