PSPHL and breast cancer in African American women: causative gene or population stratification?
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ABSTRACT:
SUBMITTER: Rummel S
PROVIDER: S-EPMC3994543 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
PSPHL and breast cancer in African American women: causative gene or population stratification?
Rummel Seth S Penatzer Cayla E CE Shriver Craig D CD Ellsworth Rachel E RE
BMC genetics 20140320
<h4>Background</h4>Phophoserine phosphatase-like (PSPHL) is expressed at significantly higher levels in breast tumors from African American women (AAW) compared to Caucasian women (CW). How overexpression of PSPHL contributes to outcome disparities is unclear, thus, molecular mechanisms driving expression differences between populations were evaluated.<h4>Results</h4>PCR was used to detect deletion of 30-Kb of chromosome 7p11 including the first three exons of PSPHL using genomic DNA from AAW (1 ...[more]
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