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Sedentary time and breast cancer incidence in African American women.

ABSTRACT: The objective of this study was to evaluate whether time spent sitting at work or watching television was associated with breast cancer risk among African American women.The Black Women's Health Study (analytic cohort = 46,734) is an ongoing prospective cohort study of African American women ages 21-69 at baseline (1995). Questionnaire data were used to estimate sedentary time. Total time spent sitting at work and watching television (individually and combined) at baseline and updated through follow-up (1995-2001) and breast cancer incidence (n = 2,041 incident cases, 1995-2013) was evaluated using proportional hazards regression.Higher total time spent sitting at baseline (?10 vs. <5 h/day, HR 1.27, 95 % CI 1.06, 1.53) and updated through follow-up (?10 vs. <5 h/day, HR 1.38, 95 % CI 1.14, 1.66) was associated with an increased breast cancer risk. Associations were stronger for hormone receptor-negative tumors (?10 vs. <5 h/day, HR 1.70, 95 % CI 1.12, 2.55) compared to hormone receptor-positive tumors (?10 vs. <5 h/day, HR 1.16, 95 % CI 0.88, 1.52), but tests for heterogeneity were not statistically significant (p heterogeneity = 0.31). Positive associations between total time spent sitting and breast cancer incidence did not differ by physical activity level or body composition measurements.Our findings suggest that high sedentary time may increase risk for breast cancer among African American women.

SUBMITTER: Nomura SJ

PROVIDER: S-EPMC5527706 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Sedentary time and breast cancer incidence in African American women.

Nomura Sarah J O SJ Dash Chiranjeev C Rosenberg Lynn L Palmer Julie J Adams-Campbell Lucile L LL

Cancer causes & control : CCC 20160908 10

<h4>Purpose</h4>The objective of this study was to evaluate whether time spent sitting at work or watching television was associated with breast cancer risk among African American women.<h4>Methods</h4>The Black Women's Health Study (analytic cohort = 46,734) is an ongoing prospective cohort study of African American women ages 21-69 at baseline (1995). Questionnaire data were used to estimate sedentary time. Total time spent sitting at work and watching television (individually and combined) at ...[more]

PMID: 27632430

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Project description:African Americans have a disproportionate burden of aggressive young-onset breast cancer. Genomic testing for inherited predisposition to breast cancer is increasingly common in clinical practice, but comprehensive mutation profiles remain unknown for most minority populations. We evaluated 289 patients who self-identified as African American with primary invasive breast cancer and with personal or family cancer history or tumor characteristics associated with high genetic risk for all classes of germline mutations in known breast cancer susceptibility genes using a validated targeted capture and multiplex sequencing approach. Sixty-eight damaging germline mutations were identified in 65 (22 %, 95 % CI 18-28 %) of the 289 subjects. Proportions of patients with unequivocally damaging mutations in a breast cancer gene were 26 % (47/180; 95 % confident interval [CI] 20-33 %) of those with breast cancer diagnosis before age 45; 25 % (26/103; 95 % CI 17-35 %) of those with triple-negative breast cancer (TNBC); 29 % (45/156; 95 % CI 22-37 %) of those with a first or second degree relative with breast cancer before age 60 or with ovarian cancer; and 57 % (4/7; 95 % CI 18-90 %) of those with both breast and ovarian cancer. Of patients with mutations, 80 % (52/65) carried mutations in BRCA1 and BRCA2 genes and 20 % (13/65) carried mutations in PALB2, CHEK2, BARD1, ATM, PTEN, or TP53. The mutational allelic spectrum was highly heterogeneous, with 57 different mutations in 65 patients. Of patients meeting selection criteria other than family history (i.e., with young age at diagnosis or TNBC), 48 % (64/133) had very limited information about the history of cancer in previous generations of their families. Mutations in BRCA1 and BRCA2 or another breast cancer gene occur in one in four African American breast cancer patients with early onset disease, family history of breast or ovarian cancer, or TNBC. Each of these criteria defines patients who would benefit from genomic testing and novel therapies targeting DNA repair pathways.

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Sedentary time and breast cancer incidence in African American women.

Publications

Sedentary time and breast cancer incidence in African American women.

Similar Datasets

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