Dataset Information

Burden of total and cause-specific mortality related to tobacco smoking among adults aged ? 45 years in Asia: a pooled analysis of 21 cohorts.

ABSTRACT:

Background

Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest.

Methods and findings

We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We then estimated smoking-related deaths among adults aged ?45 y in 2004 in Bangladesh, India, mainland China, Japan, Republic of Korea, Singapore, and Taiwan-accounting for ?71% of Asia's total population. An approximately 1.44-fold (95% CI?=?1.37-1.51) and 1.48-fold (1.38-1.58) elevated risk of death from any cause was found in male and female ever-smokers, respectively. In 2004, active tobacco smoking accounted for approximately 15.8% (95% CI?=?14.3%-17.2%) and 3.3% (2.6%-4.0%) of deaths, respectively, in men and women aged ?45 y in the seven countries/regions combined, with a total number of estimated deaths of ?1,575,500 (95% CI?=?1,398,000-1,744,700). Among men, approximately 11.4%, 30.5%, and 19.8% of deaths due to cardiovascular diseases, cancer, and respiratory diseases, respectively, were attributable to tobacco smoking. Corresponding proportions for East Asian women were 3.7%, 4.6%, and 1.7%, respectively. The strongest association with tobacco smoking was found for lung cancer: a 3- to 4-fold elevated risk, accounting for 60.5% and 16.7% of lung cancer deaths, respectively, in Asian men and East Asian women aged ?45 y.

Conclusions

Tobacco smoking is associated with a substantially elevated risk of mortality, accounting for approximately 2 million deaths in adults aged ?45 y throughout Asia in 2004. It is likely that smoking-related deaths in Asia will continue to rise over the next few decades if no effective smoking control programs are implemented. Please see later in the article for the Editors' Summary.

SUBMITTER: Zheng W

PROVIDER: S-EPMC3995657 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Burden of total and cause-specific mortality related to tobacco smoking among adults aged ≥ 45 years in Asia: a pooled analysis of 21 cohorts.

Zheng Wei W McLerran Dale F DF Rolland Betsy A BA Fu Zhenming Z Boffetta Paolo P He Jiang J Gupta Prakash Chandra PC Ramadas Kunnambath K Tsugane Shoichiro S Irie Fujiko F Tamakoshi Akiko A Gao Yu-Tang YT Koh Woon-Puay WP Shu Xiao-Ou XO Ozasa Kotaro K Nishino Yoshikazu Y Tsuji Ichiro I Tanaka Hideo H Chen Chien-Jen CJ Yuan Jian-Min JM Ahn Yoon-Ok YO Yoo Keun-Young KY Ahsan Habibul H Pan Wen-Harn WH Qiao You-Lin YL Gu Dongfeng D Pednekar Mangesh Suryakant MS Sauvaget Catherine C Sawada Norie N Sairenchi Toshimi T Yang Gong G Wang Renwei R Xiang Yong-Bing YB Ohishi Waka W Kakizaki Masako M Watanabe Takashi T Oze Isao I You San-Lin SL Sugawara Yumi Y Butler Lesley M LM Kim Dong-Hyun DH Park Sue K SK Parvez Faruque F Chuang Shao-Yuan SY Fan Jin-Hu JH Shen Chen-Yang CY Chen Yu Y Grant Eric J EJ Lee Jung Eun JE Sinha Rashmi R Matsuo Keitaro K Thornquist Mark M Inoue Manami M Feng Ziding Z Kang Daehee D Potter John D JD

PLoS medicine 20140422 4

<h4>Background</h4>Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest.<h4>Methods and findings</h4>We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We ...[more]

PMID: 24756146

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