Ontology highlight
ABSTRACT:
SUBMITTER: Inada S
PROVIDER: S-EPMC3997424 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Inada Shin S Zhang Henggui H Tellez James O JO Shibata Nitaro N Nakazawa Kazuo K Kamiya Kaichiro K Kodama Itsuo I Mitsui Kazuyuki K Dobrzynski Halina H Boyett Mark R MR Honjo Haruo H
PloS one 20140423 4
The sinoatrial node (SAN) is heterogeneous in terms of cell size, ion channels, current densities, connexins and electrical coupling. For example, Nav1.5 (responsible for INa) and Cx43 (responsible for electrical coupling) are absent from the centre of the SAN (normally the leading pacemaker site), but present in the periphery (at SAN-atrial muscle junction). To test whether the heterogeneity is important for the functioning of the SAN, one- and two-dimensional models of the SAN and surrounding ...[more]