Unknown

Dataset Information

0

Serum metabolic profiles in overweight and obese women with and without metabolic syndrome.


ABSTRACT:

Objective

To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body weight and fat mass.

Methods

We applied nuclear magnetic resonance spectroscopy-based profiling of fasting serum samples to examine the metabolic differences between 78 previously physically inactive, body weight and fat mass matched overweight/obese premenopausal women with and without MetS. MetS was defined as the presence of at least three of the following five criteria: waist circumference ?88 cm, serum triacylglycerol ?1.7 mmol/L, and high density lipoprotein cholesterol (HDL-C) <1.30 mmol/L, blood pressure???130/85 mmHg and fasting glucose ?5.6 mmol/L). Principal component analysis was used to reduce the large number of correlated variables to fewer uncorrelated factors.

Results

Two metabolic factors were associated with MetS independent of BMI, fat mass, waist circumference and physical activity/fitness. Factor comprising branched-chain amino acids (BCAA) and aromatic amino acids (AAA) and orosomucoid was associated with all clinical risk factors (p?ConclusionTwo metabolic factors distinguish overweight/obese women with metabolic syndrome from those who are metabolically healthy independent of body weight, fat mass and physical activity/fitness. In particular, factor comprising BCAA, AAA and orosomucoid seems auspicious biomarker determining metabolic health as it was associated with all clinical risk factors. Further research is needed to determine the public health and clinical significance of these results in terms of screening to identify those at greatest cardio-metabolic risk for whom appropriate intervention strategies should be developed.

SUBMITTER: Wiklund PK 

PROVIDER: S-EPMC3998195 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Serum metabolic profiles in overweight and obese women with and without metabolic syndrome.

Wiklund Petri K PK   Pekkala Satu S   Autio Reija R   Munukka Eveliina E   Xu Leiting L   Saltevo Juha J   Cheng Shumei S   Kujala Urho M UM   Alen Markku M   Cheng Sulin S  

Diabetology & metabolic syndrome 20140320 1


<h4>Objective</h4>To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body weight and fat mass.<h4>Methods</h4>We applied nuclear magnetic resonance spectroscopy-based profiling of fasting serum samples to examine the metabolic differences between 78 previously physically inactive, body weight and fat mass matched overweight/obese premenopausal wom  ...[more]

Similar Datasets

| S-EPMC10016645 | biostudies-literature
2016-03-15 | E-MTAB-3017 | biostudies-arrayexpress
| S-EPMC3646790 | biostudies-literature
| S-EPMC5907715 | biostudies-literature
| S-EPMC8188979 | biostudies-literature
| S-EPMC10544902 | biostudies-literature
| S-EPMC5018036 | biostudies-literature
| S-EPMC7475181 | biostudies-literature
| S-EPMC9486461 | biostudies-literature
| S-EPMC3849029 | biostudies-literature