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Gold-catalyzed enantioselective ring-expanding cycloisomerization of cyclopropylidene bearing 1,5-enynes.

ABSTRACT: An enantioselective ring-expanding cycloisomerization of 1,5-enynes bearing a cyclopropylidene moiety has been developed. This methodology provides a new approach to bicyclo[4.2.0]octanes, a structural motif present in many biologically active natural products.

SUBMITTER: Zheng H

PROVIDER: S-EPMC3998771 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Gold-catalyzed enantioselective ring-expanding cycloisomerization of cyclopropylidene bearing 1,5-enynes.

Zheng Hongchao H Felix Ryan J RJ Gagné Michel R MR

Organic letters 20140331 8

An enantioselective ring-expanding cycloisomerization of 1,5-enynes bearing a cyclopropylidene moiety has been developed. This methodology provides a new approach to bicyclo[4.2.0]octanes, a structural motif present in many biologically active natural products. ...[more]

PMID: 24684491

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