Family-based analysis identified CD2 as a susceptibility gene for primary open angle glaucoma in Chinese Han population.
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ABSTRACT:
SUBMITTER: Liu T
PROVIDER: S-EPMC4000112 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Family-based analysis identified CD2 as a susceptibility gene for primary open angle glaucoma in Chinese Han population.
Liu Ting T Xie Lin L Ye Jian J He Xiangge X
Journal of cellular and molecular medicine 20140306 4
Primary open angle glaucoma (POAG) is characterized by optic disc cupping and irreversible loss of retinal ganglion cells. Few genes have been detected that influence POAG susceptibility and little is known about its genetic architecture. In this study, we employed exome sequencing on three members from a high frequency POAG family to identify the risk factors of POAG in Chinese population. Text-mining method was applied to identify genes associated with glaucoma in literature, and protein-prote ...[more]
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