Ontology highlight
ABSTRACT:
SUBMITTER: Singh LN
PROVIDER: S-EPMC6138263 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Singh Larry N LN Crowston Jonathan G JG Lopez Sanchez M Isabel G MIG Van Bergen Nicole J NJ Kearns Lisa S LS Hewitt Alex W AW Yazar Seyhan S Mackey David A DA Wallace Douglas C DC Trounce Ian A IA
Investigative ophthalmology & visual science 20180901 11
<h4>Purpose</h4>To determine whether mitochondrial DNA haplogroups or rare variants associate with primary open-angle glaucoma in subjects of European descent.<h4>Methods</h4>A case-control comparison of age- and sex-matched cohorts of 90 primary open-angle glaucoma patients and 95 population controls. Full mitochondrial DNA sequences from peripheral blood were generated by next-generation sequencing and compared to the revised Cambridge Reference Sequence to define mitochondrial haplogroups and ...[more]