Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing.

ABSTRACT: Adaptive immunity in humans is provided by hypervariable Ig-like molecules on the surface of B and T cells. The final set of these molecules in each organism is formed under the influence of two forces: individual genetic traits and the environment, which includes the diverse spectra of alien and self-antigens. Here we assess the impact of individual genetic factors on the formation of the adaptive immunity by analyzing the T-cell receptor (TCR) repertoires of three pairs of monozygous twins by next-generation sequencing. Surprisingly, we found that an overlap between the TCR repertoires of monozygous twins is similar to an overlap between the TCR repertoires of nonrelated individuals. However, the number of identical complementary determining region 3 sequences in two individuals is signi

SUBMITTER: Zvyagin IV 

PROVIDER: S-EPMC4000852 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature