Ontology highlight
ABSTRACT:
SUBMITTER: Salloum D
PROVIDER: S-EPMC4001122 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Salloum Darin D Mukhopadhyay Suman S Tung Kaity K Polonetskaya Aleksandra A Foster David A DA
Molecular cancer therapeutics 20140116 3
The conversion of normal cells to cancer cells involves a shift from catabolic to anabolic metabolism involving increased glucose uptake and the diversion of glycolytic intermediates into nucleotides, amino acids, and lipids needed for cell growth. An underappreciated aspect of nutrient uptake is the utilization of serum lipids. We investigated the dependence of human cancer cells on serum lipids and report here that Ras-driven human cancer cells are uniquely dependent on serum lipids for both p ...[more]